A new approach to the solid-phase peptide synthesis of peptide alkyl-amides and esters
✍ Scribed by Ernesto Nicolás; Javier Clemente; Margarita Perelló; Fernando Albericio; Enrique Pedroso; Ernest Giralt
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- French
- Weight
- 338 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0040-4039
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## Abstract In this paper we describe the synthesis of chiral peptide nucleic acids (PNAs) 1–3 using SPPS methodologies. Starting material for the monomer units was the commercially available amino acid ornithine. l‐ or D‐ornithine and the nucleobase thymine were linked by a carboxymethylene spacer
A new aminoethyl-polystyrene linker, stable at low concentrations of TFA, has been developed for the solid phase synthesis of peptide amides. The described linker is stable under conditions which remove Bu(t) protecting groups (30-50% TFA in DCM) and the desired product can be finally cleaved off th