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Polymer-bound TBTU as a new solid-supported reagent for peptide synthesis

✍ Scribed by Rafael Chinchilla; David J Dodsworth; Carmen Nájera; José M Soriano

Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
128 KB
Volume
41
Category
Article
ISSN
0040-4039

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✦ Synopsis

A new polymer-supported TBTU (P-TBTU) has been prepared from polystyrene-bound 1-hydroxybenzotriazole (P-HOBT) and used efficiently as a solid-supported reagent for peptide-coupling reactions, and is even effective with wet solvents. The P-HOBT can be recovered by simple filtration and reused for the preparation of new P-TBTU.

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✍ Rafael Chinchilla; David J Dodsworth; Carmen Nájera; José M Soriano 📂 Article 📅 2001 🏛 Elsevier Science 🌐 French ⚖ 61 KB

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New ammonium and alkylammonium salts derived from a polymeric N-hydroxysuccinimide (P-HOSu) have been prepared and used for the amidation of carboxylic acids and amino acids mediated by 1-ethyl-3-(3%-dimethylamino-propyl)carbodiimide hydrochloride (EDC). These polymer-supported ammonium salts afford