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Ammonium salts from polymer-bound N-hydroxysuccinimide as solid-supported reagents for EDC-mediated amidations

✍ Scribed by Rafael Chinchilla; David J Dodsworth; Carmen Nájera; José M Soriano

Publisher
Elsevier Science
Year
2003
Tongue
French
Weight
106 KB
Volume
44
Category
Article
ISSN
0040-4039

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✦ Synopsis

New ammonium and alkylammonium salts derived from a polymeric N-hydroxysuccinimide (P-HOSu) have been prepared and used for the amidation of carboxylic acids and amino acids mediated by 1-ethyl-3-(3%-dimethylamino-propyl)carbodiimide hydrochloride (EDC). These polymer-supported ammonium salts afforded the corresponding amides in good yield, without detectable a-racemization and with easy recovery of the P-HOSu after the amidation reaction, being especially suitable for the amidation of Fmoc-protected amino acids.

📜 SIMILAR VOLUMES

Polymer-bound N-hydroxysuccinimide as a
Polymer-bound N-hydroxysuccinimide as a solid-supported additive for DCC-mediated peptide synthesis
✍ Rafael Chinchilla; David J Dodsworth; Carmen Nájera; José M Soriano 📂 Article 📅 2001 🏛 Elsevier Science 🌐 French ⚖ 61 KB

Polymer-supported N-hydroxysuccinimide (P-HOSu) has been prepared from a styrene/maleic anhydride co-polymer and used as an easily removable activating and racemization-reducing additive for the peptide coupling of amino acid derivatives using DCC.