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Polymer-bound N-hydroxysuccinimide as a solid-supported additive for DCC-mediated peptide synthesis

✍ Scribed by Rafael Chinchilla; David J Dodsworth; Carmen Nájera; José M Soriano

Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
61 KB
Volume
42
Category
Article
ISSN
0040-4039

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✦ Synopsis

Polymer-supported N-hydroxysuccinimide (P-HOSu) has been prepared from a styrene/maleic anhydride co-polymer and used as an easily removable activating and racemization-reducing additive for the peptide coupling of amino acid derivatives using DCC.

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