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A new route to 1,1-difluoroolefins from carboxylic acids

✍ Scribed by Kyung-Il Kim; James R. McCarthy


Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
243 KB
Volume
37
Category
Article
ISSN
0040-4039

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A new method for the synthesis of various l,l-difluoroolefins is described. The key step is the treaUnent of l-bromo-l,l-difluoro-2-alkenes with organo-raetallic reagents in the presence of copper and lithium salts.

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The transformation of bromides (I) (prepared via a previously reported reaction of aldehydes/ketones with difluorovinyllithium) to (III) and ( VI) represents a general and highly regioselective methodology for the introduction of a difluorovinylic group. The silylated products (VI) are useful precur