The transformation of bromides (I) (prepared via a previously reported reaction of aldehydes/ketones with difluorovinyllithium) to (III) and ( VI) represents a general and highly regioselective methodology for the introduction of a difluorovinylic group. The silylated products (VI) are useful precur
A new route to 1,1-difluoroolefins
✍ Scribed by Frédérique Tellier; Monique Baudry; Raymond Sauvêtre
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- French
- Weight
- 205 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
A new method for the synthesis of various l,l-difluoroolefins is described. The key step is the treaUnent of l-bromo-l,l-difluoro-2-alkenes with organo-raetallic reagents in the presence of copper and lithium salts.
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