A Simple Route to 6- and 7-Fluoro-Substituted Naphthalene-1-carboxylic Acids.
✍ Scribed by Thomas M. Kruelle; Oscar Barba; Susan H. Davis; Graham Dawson; Martin J. Procter; Thomas Staroske; Gerard H. Thomas
- Publisher
- John Wiley and Sons
- Year
- 2007
- Weight
- 26 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0931-7597
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📜 SIMILAR VOLUMES
A simple and convenient synthetic approach to the new series of 1,2,3,4,5,6,7,8octahydro-l,6-naphthyridines la-j has been developed. This was achieved via a one-pot process combining metalated 4-piperidinonimine alkylation and intramolecular eyclization.
## Abstract Alkylation of 6,7‐difluoro‐4‐hydroxyquinoline‐3‐carboxylic acid ethyl ester with substituted‐benzyl chlorides gave 1‐(substituted‐benzyl)‐6,7‐difluoro‐1,4‐dihydro‐4‐oxoquinoline‐3‐carboxylic acid ethyl esters. Their treatment with piperazine or __N__‐methylpiperazine in pyridine yielded