A New, More Efficient, and Effective Process for the Synthesis of a Key Pentacyclic Intermediate for Production of Ecteinascidin and Phthalascidin Antitumor Agents
β Scribed by Martinez, Eduardo J.; Corey, E. J.
- Book ID
- 127267158
- Publisher
- American Chemical Society
- Year
- 2000
- Tongue
- English
- Weight
- 74 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1523-7060
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
The Ziegler intermediate 2, previously used in three total syntheses of forskolin (1) has been synthesized efficiently from enone 3. The key transformation of this sequence is the early and stereoselective introduction of the C-6, C-7 oxygen functional groups present in the natural product. The hig
A simple route for the enanrioselective synthesis of key intermediates (11 and 12) for the total synthesis of forskolin has been developed starting from acid 6 and (S)-alcohol 5. The latter is prepared by enantioselective catalytic CBS reduction of dienone 3, and is converted by an intramolecular Di