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A key intermediate for the synthesis of maytansine and related antitumor agents

โœ Scribed by E.J. Corey; Mark G. Bock; A.P. Kozikowski; A.V.Rama Rao; David Floyd; Bruce Lipshutz


Book ID
108384580
Publisher
Elsevier Science
Year
1978
Tongue
French
Weight
291 KB
Volume
19
Category
Article
ISSN
0040-4039

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๐Ÿ“œ SIMILAR VOLUMES


Stereocontrolled route to a key intermed
โœ E.J. Corey; Mark G. Bock ๐Ÿ“‚ Article ๐Ÿ“… 1975 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 210 KB

We have undertaken a synthesis of this substance as part of a broader program in the area of biologically active macrocyclic natural products. One attractive approach to the synthesis of maytansine involves the introduction of chiraltty at carbons 3, 4, 5, 10, and 9 after formation of the macro ring