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A New and Efficient Synthesis of Phthalazin-1(2H)-ones

✍ Scribed by Bernard, A. M.; Cocco, M. T.; Congiu, C.; Onnis, V.; Piras, P. P.


Book ID
121655827
Publisher
Thieme Medical Publishers
Year
1998
Tongue
German
Weight
31 KB
Volume
1998
Category
Article
ISSN
0039-7881

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ChemInform Abstract: A New and Efficient
✍ A. M. BERNARD; M. T. COCCO; C. CONGIU; V. ONNIS; P. P. PIRAS πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 34 KB πŸ‘ 2 views

A New and Efficient Synthesis of Phthalazin-1(2H)-ones. -Treating readily available ethers (III) with catalytic acid under dry conditions provides an efficient synthesis of phthalazin-1(2H)-ones (IV). Using moist solvents results in hydrolysis [cf. (V)]. Treatment of (IIIa) with catalytic AlCl 3 lea