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Aluminum Chloride-Induced Heteroarylation of Arenes and Heteroarenes. 2. A New Synthesis of 4-Substituted Phthalazin-1(2 H )-ones †,1

✍ Scribed by Pal, Manojit; Batchu, Venkateswara Rao; Parasuraman, Karuppasamy; Yeleswarapu, Koteswar Rao


Book ID
120504413
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
79 KB
Volume
68
Category
Article
ISSN
0022-3263

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ChemInform Abstract: A New and Efficient
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A New and Efficient Synthesis of Phthalazin-1(2H)-ones. -Treating readily available ethers (III) with catalytic acid under dry conditions provides an efficient synthesis of phthalazin-1(2H)-ones (IV). Using moist solvents results in hydrolysis [cf. (V)]. Treatment of (IIIa) with catalytic AlCl 3 lea