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Aluminum Chloride-Induced Heteroarylation of Arenes and Heteroarenes. Part 2. A New Synthesis of 4-Substituted Phthalazin-1(2H)-ones.

✍ Scribed by Manojit Pal; Venkateswara Rao Batchu; Karuppasamy Parasuraman; Koteswar Rao Yeleswarapu


Publisher
John Wiley and Sons
Year
2003
Weight
118 KB
Volume
34
Category
Article
ISSN
0931-7597

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ChemInform Abstract: A New and Efficient
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A New and Efficient Synthesis of Phthalazin-1(2H)-ones. -Treating readily available ethers (III) with catalytic acid under dry conditions provides an efficient synthesis of phthalazin-1(2H)-ones (IV). Using moist solvents results in hydrolysis [cf. (V)]. Treatment of (IIIa) with catalytic AlCl 3 lea