ChemInform Abstract: A New and Efficient Synthesis of Phthalazin-1(2H)-ones.

✍ Scribed by A. M. BERNARD; M. T. COCCO; C. CONGIU; V. ONNIS; P. P. PIRAS

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 34 KB
• Volume: 29
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199826197

✦ Synopsis

A New and Efficient Synthesis of Phthalazin-1(2H)-ones. -Treating readily available ethers (III) with catalytic acid under dry conditions provides an efficient synthesis of phthalazin-1(2H)-ones (IV). Using moist solvents results in hydrolysis [cf. (V)]. Treatment of (IIIa) with catalytic AlCl 3 leads to a triazole derivative (VI).