A mild and highly efficient Friedländer synthesis of quinolines in the presence of heterogeneous solid acid nano-catalyst
✍ Scribed by Teimouri, Abbas; Najafi Chermahini, Alireza
- Book ID
- 120346995
- Publisher
- Elsevier
- Year
- 2016
- Tongue
- English
- Weight
- 718 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1878-5352
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📜 SIMILAR VOLUMES
## Abstract Lewis acidic ionic liquid is shown to be for the first time an excellent medium and efficient catalyst for the synthesis of quinolines at room temperature from __o__‐amino aromatic carbonyls and ketones containing active methylene group.
Poly-substituted quinolines were synthesized in the presence of a catalytic amount of dodecylphosphonic acid (DPA) in aqueous media and solvent-free conditions. The reactions proceed very well under relatively mild conditions, and DPA can be recycled.
## Abstract A rapid and an efficient method for the preparation of a variety of substituted quinolines has been developed through the reactions of __o__‐aminoarylketones with carbonyl compounds containing a reactive α‐methylene moiety in the presence of molten [Et~3~NH][HSO~4~] under solvent‐free c