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A mechanistic study of the FK-506 tricarbonyl system rearrangement: Synthesis of C.9 Labeled FK-506

✍ Scribed by D. Askin; R.A. Reamer; Daisy Joe; R.P. Volante; I. Shinkai

Publisher
Elsevier Science
Year
1989
Tongue
French
Weight
201 KB
Volume
30
Category
Article
ISSN
0040-4039

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Summan: Thu strategy usnd in the synthesis of thu C&s sngmont of A<506 is duscribed. The potent immunosuppnrtiw proportia of FKS6, 1, a macrolido produd by Shpfomyces fsddaonsis', was fin) doscribod by O&iii ot al.\* in 1987. FK5M is structurally unrelated to cyclosporin A but shores many of its pro