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Studies directed towards the synthesis of immunosuppressive agent FK-506: Construction of the tricarbonyl moiety

โœ Scribed by AV Rama Rao; T.K. Chakraborty; K Laxma Reddy


Publisher
Elsevier Science
Year
1990
Tongue
French
Weight
219 KB
Volume
31
Category
Article
ISSN
0040-4039

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The C28-C32 cyclohexyl group of the natural product, FK-506, was prepared enantioselectively from the iodolactor~ by replacement of iodide with retention of configuration. The C27-C28 trisubstituted olefin was introduced stereoselectively via a classical aldol/elimination sequence employing titanium