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Synthetic studies on the immunosuppressive agent FK-506: Construction of the polycarbonyl region

โœ Scribed by Kathleen M. Rupprecht; Robert K. Baker; Joshua Boger; Alita A. Davis; Paul J. Hodges; Joanne F. Kinneary

Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
263 KB
Volume
39
Category
Article
ISSN
0040-4039

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Beckmann rearrangement of FK506 E-oxime gave amide 2 and the fragmentation product 4. Compound 4 was atso prepared by total synthesis. The immunosuppressant FK506 has been the subject of considerabie synthetic' and degradative2 studies. As part of our pmgramme in this area we investigated the stNdU