An efficient approach has been developed to construct the entire TOP-HALF of FK-506 involving Grignard reaction of a C-28 bromide with a C-27 methylketo fragment.
โฆ LIBER โฆ
Studies directed towards the synthesis of immunosuppressive agent FK-506 : Synthesis of the entire bottom-half
โ Scribed by AV Rama Rao; TK Chakraborty; K Laxma Reddy
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- French
- Weight
- 239 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
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The synthesis of the cyclohexyl moiety of FK-505 and its coupling reaction with the CIo-CZ6fragment to provide an advanced synthetic intermediate(Clo\_Cjq) are described,