The C28-C32 cyclohexyl group of the natural product, FK-506, was prepared enantioselectively from the iodolactor~ by replacement of iodide with retention of configuration. The C27-C28 trisubstituted olefin was introduced stereoselectively via a classical aldol/elimination sequence employing titanium
✦ LIBER ✦
Synthetic studies towards the immunosuppressant FK-506 synthesis of the C10C34 fragment
✍ Scribed by Zhaoyin Wang
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- French
- Weight
- 273 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
The synthesis of the cyclohexyl moiety of FK-505 and its coupling reaction with the CIo-CZ6fragment to provide an advanced synthetic intermediate(Clo_Cjq) are described,
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