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Diastereospecific, non-racemic synthesis of the C.20–C.34 segment of the novel immunosuppressant FK-506

✍ Scribed by S. Mills; R. Desmond; R.A. Reamer; R.P. Volante; I. Shinkai


Publisher
Elsevier Science
Year
1988
Tongue
French
Weight
207 KB
Volume
29
Category
Article
ISSN
0040-4039

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A simple, enantiocontrolled and efficient route to an intermediate containing carbons 18 to 35 of the macrocyclic immunosuppressant FK-506 (1) is described which depends on a sequence of three enantioselective C-C bond forming reactions. Research in our group has recently led to the development of n