A diastereospecific, non-racemic synthesis of the C.10–C.18 segment of FK-506
✍ Scribed by D. Askin; R.P. Volante; R.A. Reamer; K.M. Ryan; I. Shinkai
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- French
- Weight
- 214 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
A simple, enantiocontrolled and efficient route to an intermediate containing carbons 18 to 35 of the macrocyclic immunosuppressant FK-506 (1) is described which depends on a sequence of three enantioselective C-C bond forming reactions. Research in our group has recently led to the development of n
Summan: Thu strategy usnd in the synthesis of thu C&s sngmont of A<506 is duscribed. The potent immunosuppnrtiw proportia of FKS6, 1, a macrolido produd by Shpfomyces fsddaonsis', was fin) doscribod by O&iii ot al.\* in 1987. FK5M is structurally unrelated to cyclosporin A but shores many of its pro