✦ LIBER ✦

A synthesis of the C16-C23 segment of FK-506

✍ Scribed by Michael Stocks; Philip Kocleński; David K. Donald

Publisher: Elsevier Science
Year: 1990
Tongue: French
Weight: 267 KB
Volume: 31
Category: Article
ISSN: 0040-4039
DOI: 10.1016/0040-4039(90)80037-m

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

A synthesis of the C(1)-C(15) segment of

A synthesis of the C(1)-C(15) segment of tsukubaenolide (FK 506).

✍ Philip Kocienski; Michael Stocks; David Donald; Martin Cooper; Anthony Manners 📂 Article 📅 1988 🏛 Elsevier Science 🌐 French ⚖ 218 KB

Synthesis of the C10-C34 segment of the

Synthesis of the C10-C34 segment of the immunosuppressant FK506

✍ Rui-Lin Gu; Charles J. Sih 📂 Article 📅 1990 🏛 Elsevier Science 🌐 French ⚖ 221 KB

A diastereospecific, non-racemic synthes

A diastereospecific, non-racemic synthesis of the C.10–C.18 segment of FK-506

✍ D. Askin; R.P. Volante; R.A. Reamer; K.M. Ryan; I. Shinkai 📂 Article 📅 1988 🏛 Elsevier Science 🌐 French ⚖ 214 KB

Diastereospecific, non-racemic synthesis

Diastereospecific, non-racemic synthesis of the C.20–C.34 segment of the novel immunosuppressant FK-506

✍ S. Mills; R. Desmond; R.A. Reamer; R.P. Volante; I. Shinkai 📂 Article 📅 1988 🏛 Elsevier Science 🌐 French ⚖ 207 KB

Studies directed towards the total synth

Studies directed towards the total synthesis of FK-506 preparation of a C(1) to C(15) segment

✍ Robert E Ireland; Peter Wipf 📂 Article 📅 1989 🏛 Elsevier Science 🌐 French ⚖ 254 KB

The protected C(1) to C(15) segment of FK-506 has been prepared from D-glucose, glycolic and L-pipecolic acid. The novel, highly active immunosuppressive agent FK-506 (1) has attracted considerable attention.1 The biological potency as well as some unique structural features render this 23-membered

Enantioselective synthesis of the C(18)

Enantioselective synthesis of the C(18) – C(35) segment of immunosuppressant FK-506 using efficient new methodology

✍ E.J Corey; Horng-Chih Huang 📂 Article 📅 1989 🏛 Elsevier Science 🌐 French ⚖ 286 KB

A simple, enantiocontrolled and efficient route to an intermediate containing carbons 18 to 35 of the macrocyclic immunosuppressant FK-506 (1) is described which depends on a sequence of three enantioselective C-C bond forming reactions. Research in our group has recently led to the development of n