A synthesis of the C(1)-C(15) segment of tsukubaenolide (FK 506).
β Scribed by Philip Kocienski; Michael Stocks; David Donald; Martin Cooper; Anthony Manners
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- French
- Weight
- 218 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0040-4039
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A simple, enantiocontrolled and efficient route to an intermediate containing carbons 18 to 35 of the macrocyclic immunosuppressant FK-506 (1) is described which depends on a sequence of three enantioselective C-C bond forming reactions. Research in our group has recently led to the development of n