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A high-performance liquid chromatographic method for the determination of stobadin pharmacokinetics in serum

✍ Scribed by Ladislav Šoltés; Zoltán Kállay; Štefan Bezek; Viera Fedelesǒvá

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
303 KB
Volume
12
Category
Article
ISSN
0142-2782

No coin nor oath required. For personal study only.

✦ Synopsis

A high-performance liquid chromatographic method was developed to determine stobadin pharmacokinetics in dog and man. The relative bioavailability of stobadin dipalmitate compared with dihydrochloride was 46.4 per cent in dog. In man peak serum concentrations ranged from 12 to 289 ng ml-1 after a single oral dose of stobadin dipalmitate (0.79 to 2.5 mgkg-1).

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