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A General Synthesis of C2'-Deuterated Ribonucleosides

✍ Scribed by Cook, Gary P.; Greenberg, Marc M.


Book ID
121341577
Publisher
American Chemical Society
Year
1994
Tongue
English
Weight
407 KB
Volume
59
Category
Article
ISSN
0022-3263

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## Abstract New syntheses of __C__(2′)‐deuterated ribonucleosides have been accomplished starting either from 3,5‐di‐__O__‐benzyl‐1‐__O__‐methyl‐__α__,__β__‐D‐ribofuranose (**1b**) or 2,3‐__O__‐isopropylidene‐D‐ribose (**14**), with >97 atom‐% D incorporation in both cases. The former is suited to