A General Synthesis of C2'-Deuterated Ribonucleosides
✍ Scribed by Cook, Gary P.; Greenberg, Marc M.
- Book ID
- 121341577
- Publisher
- American Chemical Society
- Year
- 1994
- Tongue
- English
- Weight
- 407 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0022-3263
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📜 SIMILAR VOLUMES
## Abstract A general way for the functionalization of ribonucleosides is described. The method involves the synthesis of the methyl‐ribofuranoside derivative 6 equipped with a linker at the 2‐hydroxy group (__Scheme 2__). After introduction of the nucleic‐acid bases under standard conditions (__Sc
## Abstract New syntheses of __C__(2′)‐deuterated ribonucleosides have been accomplished starting either from 3,5‐di‐__O__‐benzyl‐1‐__O__‐methyl‐__α__,__β__‐D‐ribofuranose (**1b**) or 2,3‐__O__‐isopropylidene‐D‐ribose (**14**), with >97 atom‐% D incorporation in both cases. The former is suited to