## Dedicated to Prof. Dr. Frank Seela on the occasion of his 60th birthday The preparation of building blocks for the incorporation of 6'-O-(5-bromopentyl)-substituted b-dallofuranosylnucleosides and 2'-O-[(3-bromopropoxy)methyl]-substituted ribonucleosides into oligonucleotide sequences is presen
Synthesis of 2′-O-Substituted Ribonucleosides
✍ Scribed by V. Serebryany; L. Beigelman
- Publisher
- John Wiley and Sons
- Year
- 2004
- Weight
- 50 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0931-7597
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📜 SIMILAR VOLUMES
## Abstract New syntheses of __C__(2′)‐deuterated ribonucleosides have been accomplished starting either from 3,5‐di‐__O__‐benzyl‐1‐__O__‐methyl‐__α__,__β__‐D‐ribofuranose (**1b**) or 2,3‐__O__‐isopropylidene‐D‐ribose (**14**), with >97 atom‐% D incorporation in both cases. The former is suited to
## Abstract A general way for the functionalization of ribonucleosides is described. The method involves the synthesis of the methyl‐ribofuranoside derivative 6 equipped with a linker at the 2‐hydroxy group (__Scheme 2__). After introduction of the nucleic‐acid bases under standard conditions (__Sc