## Abstract A general way for the functionalization of ribonucleosides is described. The method involves the synthesis of the methyl‐ribofuranoside derivative 6 equipped with a linker at the 2‐hydroxy group (__Scheme 2__). After introduction of the nucleic‐acid bases under standard conditions (__Sc
✦ LIBER ✦
General preparative synthesis of 2′-O-methylpyrimidine ribonucleosides
✍ Scribed by B. S. Ross; R. H. Springer; G. Vasquez; R. S. Andrews; P. D. Cook; O. L. Acevedo
- Book ID
- 112130948
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 1994
- Tongue
- English
- Weight
- 431 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0022-152X
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## Abstract New syntheses of __C__(2′)‐deuterated ribonucleosides have been accomplished starting either from 3,5‐di‐__O__‐benzyl‐1‐__O__‐methyl‐__α__,__β__‐D‐ribofuranose (**1b**) or 2,3‐__O__‐isopropylidene‐D‐ribose (**14**), with >97 atom‐% D incorporation in both cases. The former is suited to