A general approach to N-heterocyclic scaffolds using domino Heck–aza-Michael reactions
✍ Scribed by Priebbenow, Daniel L.; Stewart, Scott G.; Pfeffer, Frederick M.
- Book ID
- 118210287
- Publisher
- Royal Society of Chemistry
- Year
- 2011
- Tongue
- English
- Weight
- 441 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1477-0520
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A one-pot, three-component method incorporating a domino Heck-aza-Michael reaction has been developed for the rapid synthesis of functionalised tetrahydroisoquinolines. Following the in situ generation of an acrylamide, a domino process [a
## Abstract The development of hydroformylative domino reactions of easily accessible vinyl acetamides is described. Extremely regioselective hydroformylation of terminal double bounds provides a transient __N__‐acyliminium that can be trapped by various nucleophiles to give several aza‐heterocylic