A One-Pot, Three-Component Approach to Functionalised Tetrahydroisoquinolines Using Domino Heck–aza-Michael Reactions

✍ Scribed by Daniel L. Priebbenow; Frederick M. Pfeffer; Scott G. Stewart

• Publisher: John Wiley and Sons
• Year: 2011
• Tongue: English
• Weight: 316 KB
• Volume: 2011
• Category: Article
• ISSN: 1434-193X
• DOI: 10.1002/ejoc.201001621

✦ Synopsis

A one-pot, three-component method incorporating a domino Heck-aza-Michael reaction has been developed for the rapid synthesis of functionalised tetrahydroisoquinolines. Following the in situ generation of an acrylamide, a domino process [a