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ChemInform Abstract: A General Approach to N-Heterocyclic Scaffolds Using Domino Heck—aza-Michael Reactions.

✍ Scribed by Daniel L. Priebbenow; Scott G. Stewart; Frederick M. Pfeffer


Publisher
John Wiley and Sons
Year
2011
Weight
31 KB
Volume
42
Category
Article
ISSN
0931-7597

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A one-pot, three-component method incorporating a domino Heck-aza-Michael reaction has been developed for the rapid synthesis of functionalised tetrahydroisoquinolines. Following the in situ generation of an acrylamide, a domino process [a