A General and Practical Synthesis of N -Aryl-3-[4-(imidazol-4-yl)-1,2,3-triazol-1-yl]benzamide Anti-Inflammatory Cytokine Inhibitors
✍ Scribed by Frutos, Rogelio P.; Rodriguez, Sonia; Patel, Nitinchandra D.; Reeves, Diana; Tampone, Thomas; Senanayake, Chris H.
- Book ID
- 124078549
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 2014
- Tongue
- English
- Weight
- 276 KB
- Volume
- 3
- Category
- Article
- ISSN
- 2193-5807
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## Abstract magnified image Fourteen novel substituted __N__‐[4(5‐methyl/phenyl‐1,3,4‐oxadiazol‐2‐yl)‐3,6‐dihydropyridin‐1(2__H__)‐yl] benzamide/benzene sulfonamides (**11a**, **11b**, **11c**, **11d**, **11e**, **11f**, **11g**, **11h**, **11i**, **11j**, **11k**, **11l**, **11m**, **11n**) were
The synthesis of a series of 2-aryl-2H, 4H-imidazo[4,5-d][1,2,3]triazoles is reported. These compounds are obtained in moderate to good yield by reaction of triethyl N-1-ethyl-2-methyl-4-nitro-1H-imidazol-5yl phosphoramidate with aryl isocyanates.
## Abstract magnified image One‐pot reaction of 3‐aryl‐5‐methyl‐1,3,4‐oxadiazolin‐2‐ones **1a‐g** with ethanolamine yielded the 4‐(2‐hydroxyethyl)‐2‐aryl‐5‐methyl‐2,4‐dihydro‐3__H__‐1,2,4‐triazolin‐3‐ones **2a‐g** which were converted to the azido compounds **6a‐g**. These azides on 1,3‐dipolar cy