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A facile synthesis of sodium 3-[1-14C]-ethyl-7-isopropyl-1-azulenesulfonate

✍ Scribed by Takeshi Shimada; Takashi Yanagisawa; Tsuyoshi Tomiyama; Mitsuo Okazaki

Publisher
John Wiley and Sons
Year
1994
Tongue
French
Weight
212 KB
Volume
34
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Sodium 3‐ethyl‐7‐isopropyl‐1‐azulenesulfonate 1, a new therapeutic agent for stomatitis, pharyngitis and ophthalmia was labelled with carbon‐14 in the ethyl group attached to the azulene ring for use in metabolic studies. ^14^C‐labelled 1 with a specific activity of 1.98 GBq/mmol was prepared in four steps in 39.3% overall chemical yield from [1 ‐^14^C]acetic acid sodium salt.

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