A facile synthesis of high specific activity sodium [1-14C] lauryl sulphate under microwave irradiation

✍ Scribed by S. Ravi; K. M. Mathew; V. K. P. Unny; N. Sivaprasad

• Publisher: John Wiley and Sons
• Year: 2005
• Tongue: French
• Weight: 81 KB
• Volume: 48
• Category: Article
• ISSN: 0022-2135
• DOI: 10.1002/jlcr.966

✦ Synopsis

A highly efficient and optimized synthesis of sodium[1-14 C] lauryl sulphate having high specific activity (50 mCi/mmol) is described. Lauric acid was converted to undecyl bromide using a modified Hunsdiecker reaction. This was treated with potassium 14 C cyanide (specific activity 50 mCi/mmol) using phase transfer catalysis to yield [1-14 C]lauronitrile, which was subsequently hydrolysed with a mixture of concentrated hydrochloric acid:propionic acid (1:2 v/v) under microwave irradiation for 2 min to obtain [1-14 C] lauric acid in quantitative yield. The latter on reaction with chlorosulphonic acid and subsequent neutralization with sodium bicarbonate yielded the title compound.