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Synthesis of carbon-14-labelled antibacterial agent. Synthesis of 1-ethyl- [1-14C]-6-fluoro-1, 4-dihydro-4-oxo-7- (1-piperazinyl)-3-quinolinecarboxylic acid (14C-AM-715)

✍ Scribed by Y. Nagatsu; T. Irikura

Publisher
John Wiley and Sons
Year
1981
Tongue
French
Weight
236 KB
Volume
18
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

1‐Ethyl‐6‐fluoro‐1,4‐dihydro‐4‐oxo‐7‐(1‐piperazinyl)‐ 3‐quinolinecarboxylic acid (I, AM‐715), a new potent antibacterial agent, was labelled with carbon‐14 at the C‐1 position of the N‐ethyl group for metabolic studies. The synthesis was achieved according to two reaction routes. The overall radiochemical yields of ^14^C‐AM‐715 based on ethyl iodide‐1‐^14^C from route A and route B, were 29.4% and 9.4%, respectively.

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