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Synthesis of 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl (±)-1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-[6-14C]pyridinedicarboxylate dihydrochloride ([14C]CV-4093 (2HCl))

✍ Scribed by Norio Tada; Masahiro Kajino; Masazumi Watanabe; Nobuyoshi Hayashi

Publisher
John Wiley and Sons
Year
1989
Tongue
French
Weight
139 KB
Volume
27
Category
Article
ISSN
0022-2135

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✦ Synopsis

The carbon-I4 labelled compound ( 5 ) of 2-[4-(diphenylmethy1)-l -piperazinyl]ethyl methyl (?)-I ,$-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate dihydrochloride (CV-4093 (2HCI)) was synthesized for the study of its metabolism and distribution in test animals. Starting from the commercially available ethyl[3-' 4C]acetoacetate ( I ), 5 was prepared by a modified Hantzxh synthesis, in an overall radiochemical yield of 23.7%.

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