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Synthesis of sodium 3-ethyl-7-isopropyl-[2-14C]-azulene-1-sulfonate

✍ Scribed by Hiroaki Suzaka; Tsuyoshi Tomiyama; Shiro Ikegami

Publisher
John Wiley and Sons
Year
1990
Tongue
French
Weight
415 KB
Volume
28
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Sodium 3‐ethyl‐7‐isopropylazulene‐1‐sulfonate 1, which has been found to be a potent and chemically stable agent having anti‐inflammatory and anti‐ulcerous activity, was synthesized in ^14^C‐labelled form by using potassium [^14^C]‐cyanide. ^14^C‐Labelled 1 with a specific activity of 9.02 mCi/mmol was prepared in eight steps in 21.9% overall chemical yield from 3‐(t‐butyldiphenylsilyloxy)propyl tosylate 10.

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