𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of 2-amino-7-isopropyl-5-OXO-5H- [1] benzopyrano-[2,3-b] [2-14C]pyridine-3-carboxylic acid (AA-673-14C)

✍ Scribed by Nobuyoshi Hayashi; Masayuki Imanishi

Publisher
John Wiley and Sons
Year
1986
Tongue
French
Weight
119 KB
Volume
23
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

17-85. Jusohonmachi 2-chome, Yodogawa-ku. Osaka 532, Japan.

2-Amino

-7-isopropyl-5-0~0-5H-[ 11 benzopyrano[ 2,3-b] pyridine-3-carboxylic acid (AA-673) was found in these laboratories during the course of the studies on antiallergic agents. passive cutaneous anaphylaxis reaction in rats and the Arthus type allergy upon oral and intravenous administrations.

📜 SIMILAR VOLUMES

Synthesis of 7-chloro-1,3-dihydro-5-(2-f
Synthesis of 7-chloro-1,3-dihydro-5-(2-fluorophenyl)-1-methyl-2H-1,4-benzodiazepin-2-one-5-14C (fludiazepam-14C)
✍ Iwao Nakatsuka; Kazuo Kawahara; Takeshi Kamada; Fumiaki Shono; Akira Yoshitake 📂 Article 📅 1977 🏛 John Wiley and Sons 🌐 French ⚖ 298 KB 👁 1 views

## Abstract 7‐Chloro‐1,3‐dihydro‐5‐(2‐fluorophenyl)‐1‐methyl‐2H‐1,4‐benzodiazepin‐2‐one (Fludiazepam) (I), an anti‐anxiety agent, was labelled with carbon‐14 at C‐5 position for metabolic studies. The reaction sequence for the synthesis is shown in Fig. 2. o‐Fluorobenzoic‐^14^C acid (IV) was prepar

Synthesis of 1, 3-dihydro-1-methyl-7-nit
Synthesis of 1, 3-dihydro-1-methyl-7-nitro-5-phenyl-2H-1, 4-benzodiazepin-2-one-5-14c (nimetazepam-5-14C)
✍ A. Yoshitake; Y. Makari; M. Endo 📂 Article 📅 1972 🏛 John Wiley and Sons 🌐 French ⚖ 243 KB 👁 1 views

## Abstract The synthesis from carbon‐^14^C dioxide of 1, 3‐dihydro‐1‐methyl‐7‐nitro‐5‐phenyl‐2H‐1, 4‐benzodiazepin‐2‐one‐5‐^14^C (I) for use in metabolic studies has been described. The synthesis was achieved by the sequence shown in figure 1. The overall yield of labelled nimetazepam (I) was near

Synthesis of 7-chloro-1,3,-dihydro-3-hyd
Synthesis of 7-chloro-1,3,-dihydro-3-hydroxy-1-methyl-5-phenyl-2h-1,4-benzodiazepin-2-one-2-14c (2-14C-temazepam)
✍ Jeremy G. Dain 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 French ⚖ 217 KB 👁 1 views

Tema~epam-2-'~C, 7-Chloro-1,3-ihydro-3-hydroxy-1 -methyl-5-phenyl-2H-1,4-benzodiazepin-2-one--"C, was prepared in a f ive-step synthesis. Chl~roacetic-l-~~C acid was converted to the acid chloride with thionyl chloride. The acid chloride was allowed to react with 2-methylamino-5-chloro-benzophenone