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Synthesis of sodium 6-isopropyl-3-[4-(P-chlorobenzenesulfonylamino)-butyl]-[2-14C]azulene-1-sulfonate

✍ Scribed by Takashi Yanagisawa; Masayuki Yokota; Tsuyoshi Tomiyama; Shiro Ikegami

Publisher
John Wiley and Sons
Year
1994
Tongue
French
Weight
330 KB
Volume
34
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Sodium 6‐isopropyl‐3‐[4‐(p‐chlorobenzenesulfonylamino)‐butyl]azulene‐l‐sulfonate (KT2‐962) 1, which has been found to be a potent and selective thromboxaneA~2~ receptor antagonist, was synthesized in ^14^C‐labelled form by using potassium [^14^C]‐cyanide.

^14^C‐labelled 1 with a specific activity of 2.36 GBq/mmol was prepared with no‐carrier‐added and in nine steps in 64% overall radiochemical yield.

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