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Synthesis of 3 or 5[14C] 4-butyl-1, 2-diphenyl-3, 5-pyrazolidinedione (phenylbutazone)

✍ Scribed by S. Stavchansky; H. B. Kostenbauder

Publisher
John Wiley and Sons
Year
1972
Tongue
French
Weight
136 KB
Volume
8
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The condensation of 1 or 3 [^14^C] n‐butylmalonate diethyl ester (III) with hydrazobenzene (IV) yields up to 90 per cent of 3 or 5 [^14^C] 4‐butyl‐1, 2‐diphenyl‐3, 5‐pyrazolidinedione, if n‐butyl alcohol is used as a solvent and the corresponding sodium alcoholate as a condensing agent (1, 2).

One or three [^14^C] n ‐ butylmalonate diethyl ester can be synthesized by condensation of n‐bromobutane (II) and 1 [^14^C] ethyl malonate (I) in the presence of sodium ethoxide (3).

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