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A facile synthesis of (R)-(−)-hexahydromandelic acid with fermenting baker's yeast

✍ Scribed by Sadao Tsuboi; Emiko Nishiyama; Masanori Utaka; Akira Takeda


Publisher
Elsevier Science
Year
1986
Tongue
French
Weight
125 KB
Volume
27
Category
Article
ISSN
0040-4039

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Baker's Yeast Mediated Enantiospecific Synthesis of anti-(2R,3R)p-Chloro-3-hydroxytyrosine: An α-Amino-β-hydroxy Acid of Vancomycin. -The synthesis of the protected derivative (V) is achieved via baker's yeast-mediated reduction of the α-azido-β-keto ester (II) at pH 4.0. At pH 7.0 the enantioselect