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ChemInform Abstract: Baker′s Yeast Mediated Enantiospecific Synthesis of anti-(2R,3R)-p-Chloro-3-hydroxytyrosine: An α-Amino-β-hydroxy Acid of Vancomycin.

✍ Scribed by N. W. FADNAVIS; S. K. VADIVEL; M. SHARFUDDIN; U. T. BHALERAO

Publisher: John Wiley and Sons
Year: 2010
Weight: 34 KB
Volume: 29
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199821183

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✦ Synopsis

Baker's Yeast Mediated Enantiospecific Synthesis of anti-(2R,3R)p-Chloro-3-hydroxytyrosine: An α-Amino-β-hydroxy Acid of Vancomycin. -The synthesis of the protected derivative (V) is achieved via baker's yeast-mediated reduction of the α-azido-β-keto ester (II) at pH 4.0. At pH 7.0 the enantioselectivity is maintained, but the diastereoselectivity is lost.

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