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A Direct Catalytic Asymmetric Mannich-type Reaction to syn -Amino Alcohols

✍ Scribed by Trost, Barry M.; Terrell, Lamont R.


Book ID
120022616
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
57 KB
Volume
125
Category
Article
ISSN
0002-7863

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Direct Catalytic Asymmetric Mannich-Type
✍ Yuta Suzuki; Ryo Yazaki; Naoya Kumagai; Masakatsu Shibasaki 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 402 KB 👁 1 views

## Abstract **Weich hilft hart**: Die Titelreaktion zwischen Thioamiden und __N__‐(Diphenylphosphinoyl)iminen nutzt die kooperative Katalyse einer weichen Lewis‐Säure und einer harten Brønsted‐Base, um Thioamid‐Kohlenstoff‐Pränucleophile in Mannich‐Produkte zu überführen (siehe Schema). Folgereakti

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## Abstract **Taking the reins**: The title transformation of thioamides and __N__‐diphenylphosphinoyl imines is described. By harnessing the power of cooperative catalysis between a soft Lewis acid and a hard Brønsted base, thioamide carbon pronucleophiles can furnish Mannich products (see scheme)