A Direct Catalytic Asymmetric Mannich-type Reaction to syn -Amino Alcohols
✍ Scribed by Trost, Barry M.; Terrell, Lamont R.
- Book ID
- 120022616
- Publisher
- American Chemical Society
- Year
- 2003
- Tongue
- English
- Weight
- 57 KB
- Volume
- 125
- Category
- Article
- ISSN
- 0002-7863
No coin nor oath required. For personal study only.
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## Abstract **Weich hilft hart**: Die Titelreaktion zwischen Thioamiden und __N__‐(Diphenylphosphinoyl)iminen nutzt die kooperative Katalyse einer weichen Lewis‐Säure und einer harten Brønsted‐Base, um Thioamid‐Kohlenstoff‐Pränucleophile in Mannich‐Produkte zu überführen (siehe Schema). Folgereakti
## Abstract **Taking the reins**: The title transformation of thioamides and __N__‐diphenylphosphinoyl imines is described. By harnessing the power of cooperative catalysis between a soft Lewis acid and a hard Brønsted base, thioamide carbon pronucleophiles can furnish Mannich products (see scheme)