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A Design Alternative for Two-Stage, Phase II, Multicenter Cancer Clinical Trials

โœ Scribed by James E.Herndon II


Book ID
114187497
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
134 KB
Volume
19
Category
Article
ISSN
0197-2456

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Optimal three-stage designs for phase II
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The objective of a phase II cancer clinical trial is to screen a treatment that can produce a similar or better response rate compared to the current treatment results. This screening is usually carried out in two stages as proposed by Simon. For ineffective treatment, the trial should terminate at