The objective of a phase II cancer clinical trial is to screen a treatment that can produce a similar or better response rate compared to the current treatment results. This screening is usually carried out in two stages as proposed by Simon. For ineffective treatment, the trial should terminate at
β¦ LIBER β¦
Balanced two-stage designs for phase II clinical trials
β Scribed by Fei Ye, ; Shyr, Y.
- Book ID
- 111961148
- Publisher
- SAGE Publications
- Year
- 2007
- Tongue
- English
- Weight
- 156 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1740-7745
No coin nor oath required. For personal study only.
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In the conduct of a phase II cancer clinical trial, patients usually enter in two stages. If the response rate from the first stage is low, then the study terminates. Within various two-stage designs, Simon proposed the optimal and minimax criteria. In the co-operative group setting, practical consi