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8-Cl-adenosine induces G1 cell cycle arrest in colorectal carcinomas through p53-dependent and -independent elevations in p21WAF1/CIP1

โœ Scribed by Dransfield, Daniel T.; Burnham, Laura L.; Simonton, Stacy L.; Chinery, Rebecca


Book ID
122530741
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
171 KB
Volume
114
Category
Article
ISSN
0016-5085

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## Transforming growth factor-โค1 (TGF-โค) inhibits cell-cycle progression of many types of cells by arresting them in G 1 /S phase through inhibition of the active cyclin-Cdk complexes that lead to inhibition of Rb phosphorylation. In gastriccancer cells, SNU16, TGF-โค treatment induced enhanced exp