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Fucoxanthin induces cell cycle arrest at G0/G1 phase in human colon carcinoma cells through up-regulation of p21WAF1/Cip1

โœ Scribed by Swadesh K. Das; Takashi Hashimoto; Kazuo Shimizu; Tatsushi Yoshida; Toshiyuki Sakai; Yoshihiro Sowa; Akitoshi Komoto; Kazuki Kanazawa


Book ID
116271515
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
568 KB
Volume
1726
Category
Article
ISSN
0304-4165

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## Transforming growth factor-โค1 (TGF-โค) inhibits cell-cycle progression of many types of cells by arresting them in G 1 /S phase through inhibition of the active cyclin-Cdk complexes that lead to inhibition of Rb phosphorylation. In gastriccancer cells, SNU16, TGF-โค treatment induced enhanced exp