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Artepillin C in Brazilian propolis induces G0/G1 arrest via stimulation of Cip1/p21 expression in human colon cancer cells

โœ Scribed by Kazuo Shimizu; Swadesh K. Das; Takashi Hashimoto; Yoshihiro Sowa; Tatsushi Yoshida; Toshiyuki Sakai; Yukinaga Matsuura; Kazuki Kanazawa

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
194 KB
Volume
44
Category
Article
ISSN
0899-1987

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Pyrrolidine dithiocarbamate (PDTC), a metal chelating compound, is known to induce cell death in vascular smooth muscle cells (VSMC). However, the molecular mechanism for PDTC-induced VSMC death is not well understood. Addition of PDTC reduced cell growth and DNA synthesis on VSMC in low density con