HDAC4 represses p21WAF1/Cip1 expression in human cancer cells through a Sp1-dependent, p53-independent mechanism
✍ Scribed by Mottet, D; Pirotte, S; Lamour, V; Hagedorn, M; Javerzat, S; Bikfalvi, A; Bellahcène, A; Verdin, E; Castronovo, V
- Book ID
- 109970703
- Publisher
- Nature Publishing Group
- Year
- 2008
- Tongue
- English
- Weight
- 365 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0950-9232
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## Abstract __SDI1__ is an inhibitor of DNA synthesis that we isolated by expression screening cDNAs prepared from senescent, terminally nondividing human cells. Other groups then cloned this gene as a cyclin‐dependent kinase (cdk)‐interacting protein (CIP1, p21) that inhibits cdks; the gene was al