## Abstract __SDI1__ is an inhibitor of DNA synthesis that we isolated by expression screening cDNAs prepared from senescent, terminally nondividing human cells. Other groups then cloned this gene as a cyclinโdependent kinase (cdk)โinteracting protein (CIP1, p21) that inhibits cdks; the gene was al
โฆ LIBER โฆ
Ethanol upregulates the expression of p21WAF1/CIP1 and prolongs G1 transition via a p53-independent pathway in human epithelial cells
โ Scribed by Guo, Wentong; Baluda, Marcel A; Park, No-Hee
- Book ID
- 110060883
- Publisher
- Nature Publishing Group
- Year
- 1997
- Tongue
- English
- Weight
- 388 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0950-9232
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p21 WAF1/Cip1 is an inhibitor of cdk/cyclin complexes, and thus regulates the cell cycle. p21 is also related to cell differentiation and is regulated by wild-type p53, although p53-independent regulatory pathways have been proposed. In order to analyse p21 expression as well as its relationship wit