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4,8-Dimethoxy-1,5-naphthyridine

✍ Scribed by Harlow, R. L. ;Simonsen, S. H.


Book ID
114524422
Publisher
International Union of Crystallography
Year
1977
Weight
248 KB
Volume
33
Category
Article
ISSN
0567-7408

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Synthesis of 4,8‐Dimethoxy‐1,5‐naphthalenediol and Its Oxidation to 4,8‐Dimethoxy‐1,5‐naphthoquinone Formation of the new 1,5‐naphthoquinone 3 was achieved by methylation of 1,4,5,8‐naphthalenetetrol (1a) and oxidation of the dimethyl ether 1c obtained thereof. In the presence of water, 3 yields th

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## Abstract Ethyl 1‐ethyl‐7‐methyl‐4‐oxo‐1,4‐dihydro[1,8]naphthyridine‐3‐carboxylate (**1**), precursor of nalidixic acid, has been converted in two steps through ([1,8]naphthyridin‐3‐yl)carbonylguanidine derivatives into substituted pyrimido[4,5‐__b__] and [5,4‐__c__][1,8]naphthyridines.